http://trailfire.com/Smith/trails/33339Smith/trails60http://trailfire.com/Smith/marks/82467The site provides most important papers of 2500 international researchers and clinicians on different topics. Here you can customize the site and receive tailored e mail alerts. If you are a registered, you will have personal access here. After the subscription you will get three weeks trial. You can also access from your institute as well.

]]>Autoantibody: the shield for fitnessSmithThu, 05 Apr 2007 07:49:21 -0700trailfire:markId:82467http://trailfire.com/Smith/marks/82468Natural antibodies are autoreactive or polyreactive antibodies. It is believed to be secreted in the absence of xenoantigens. The origin and functions of this limited and selective autoimmunity are not yet clear. The range of autoantigens that drive the development of B cells producing natural antibodies is not known as well.

]]>Autoantibody: the shield for fitnessSmithThu, 05 Apr 2007 07:51:26 -0700trailfire:markId:82468http://trailfire.com/Smith/marks/82469Mutations in the CLN3 gene is the cause for the neurodegenerative disorder called Batten disease. The molecular basis of this disease is not yet known. While studying a mouse model for Batten disease, “the presence of an autoantibody to glutamic acid decarboxylase (GAD65) in cln3-knockout mice serum is found. It is associates with brain tissue.

]]>Autoantibody: the shield for fitnessSmithThu, 05 Apr 2007 07:52:04 -0700trailfire:markId:82469http://trailfire.com/Smith/marks/82470A study showed the relationship between baseline autoantibody status (rheumatoid factor and anti-CCP). It is found that patients with seronegative for these autoantibodies “achieved a significant moderate/good ACR response compared to the placebo group from a first treatment course with rituximab”. Such patients show more ACR response than placebo treated seronegative group.

]]>Autoantibody: the shield for fitnessSmithThu, 05 Apr 2007 07:52:46 -0700trailfire:markId:82470http://trailfire.com/Smith/marks/82471The site offers computer assisted result for autoantibody patterns. The site says that “Immunoassay-based anti-nuclear antibody (ANA) screens are increasingly used in the initial evaluation of autoimmune disorders, but these tests offer no “pattern information” comparable to the information from indirect fluorescence assay-based screens”.  But it is not clear when positive result is obtained.

]]>Autoantibody: the shield for fitnessSmithThu, 05 Apr 2007 07:53:31 -0700trailfire:markId:82471